Blar i forfatter "Chen, Meng"

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    • 17β-estradiol promotes extracellular vesicle release and selective miRNA loading in ERα-positive breast cancer 

      Drula, Rares; Pardini, Barbara; Fu, Xiao; De Los Santos, Mireia Cruz; Jurj, Ancuta; Pang, Lan; El-Daly, Sherien M.; Fabris, Linda; Knutsen, Erik; Dragomir, Mihnea P.; Bayraktar, Recep; Li, Yongfeng; Chen, Meng; Del Vecchio, Filippo; Berland, Léa; Dae, Jessica; Fan, Daniel; Shimizu, Masayoshi; Tran, Anh M.; Barzi, Mercedes; Pioppini, Carlotta; Gutierrez, Angelica M.; Ivan, Cristina; Meas, Salyna; Hall, Carolyn S.; Alahari, Suresh K.; Berindan-Neagoe, Ioana; Fabbri, Muller; Lucci, Anthony; Arun, Banu; Anfossi, Simone; Calin, George A. (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-05-30)
      The causes and consequences of abnormal biogenesis of extracellular vesicles (EVs) are not yet well understood in malignancies, including in breast cancers (BCs). Given the hormonal signaling dependence of estrogen receptor–positive (ER+) BC, we hypothesized that 17β-estradiol (estrogen) might influence EV production and microRNA (miRNA) loading. We report that physiological doses of 17β-estradiol ...

    • Anti–miR-93-5p therapy prolongs sepsis survival by restoring the peripheral immune response 

      Dragomir, Mihnea P.; Fuentes-Mattei, Enrique; Winkle, Melanie; Okubo, Keishi; Bayraktar, Recep; Knutsen, Erik; Qdaisat, Aiham; Chen, Meng; Li, Yongfeng; Shimizu, Masayoshi; Pang, Lan; Liu, Kevin; Liu, Xiuping; Anfossi, Simone; Zhang, Huanyu; Koch, Ines; Tran, Anh M.; Mohapatra, Swati; Ton, Anh; Kaplan, Mecit; Anderson, Matthew W.; Rothfuss, Spencer J.; Silasi, Robert; Keshari, Ravi S.; Ferracin, Manuela; Ivan, Cristina; Rodriguez-Aguayo, Cristian; Lopez-Berestein, Gabriel; Georgescu, Constantin; Banerjee, Pinaki P.; Basar, Rafet; Li, Ziyi; Horst, David; Vasilescu, Catalin; Bertilaccio, Maria Teresa S.; Rezvani, Katayoun; Lupu, Florea; Yeung, Sai-Ching; Calin, George A. (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-06-01)
      Sepsis remains a leading cause of death for humans and currently has no pathogenesis-specific therapy. Hampered progress is partly due to a lack of insight into deep mechanistic processes. In the past decade, deciphering the functions of small noncoding miRNAs in sepsis pathogenesis became a dynamic research topic. To screen for new miRNA targets for sepsis therapeutics, we used samples for miRNA ...

    • Metformin blocks MYC protein synthesis in colorectal cancer via mTOR-4EBP-eIF4E and MNK1-eIF4G-eIF4E signaling 

      Shen, Peng; Reineke, Lucas C.; Knutsen, Erik; Chen, Meng; Pichler, Martin; Ling, Hui; Calin, George A. (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-09-17)
      The antidiabetic drug metformin has been associated with reduced colorectal cancer (CRC) risk and improved prognosis of CRC patients. However, the detailed mechanisms underlying such beneficial effects remain unknown. In this study, we aimed to evaluate metformin activity in CRC models and unveil the underlying molecular mechanisms. We showed that metformin inhibits CRC cell proliferation by arresting ...

    • Serglycin is Involved in TGF-β induced epithelial-mesenchymal transition and is highly expressed by immune cells in breast cancer tissue 

      Tellez Gabriel, Marta; Tekpli, Xavier; Reine, Trine M.; Hegge, Beate; Nielsen, Stephanie Rose; Chen, Meng; Moi, Line; Normann, Lisa Svartdal; Rasmussen Busund, Lill-Tove; Calin, George A.; Mælandsmo, Gunhild Mari; Perander, Maria; Theocharis, Achilleas D.; Kolset, Svein Olav; Knutsen, Erik (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-04-14)
      Serglycin is a proteoglycan highly expressed by immune cells, in which its functions are linked to storage, secretion, transport, and protection of chemokines, proteases, histamine, growth factors, and other bioactive molecules. In recent years, it has been demonstrated that serglycin is also expressed by several other cell types, such as endothelial cells, muscle cells, and multiple types of ...